Akademik Veri Yönetim Sistemi
XI. NATIONAL / II. INTERNATIONAL CONGRESS OF VETERINARY PATHOLOGY, Erzurum, Türkiye, 4 - 08 Eylül 2023, ss.14-15, (Özet Bildiri)
The remarkable increase in lymphomas, which is expressed as the most common hematopoietic
neoplasm in dogs and is among the three most common neoplasm types in the world, and the
development of treatment options have made lymphomas an important issue in veterinary
oncology. In the study, the immunophenotype of canine lymphomas was determined with the
help of CD3, CD4, CD79α and Pax5 antibodies, and the tumors were classified into
cytomorphological and histological subtypes according to the updated Kiel and Revised
European-American Lymphoma Classification (REAL) systems. It was aimed to reveal the
relationship of these classifications with the expression levels of Bcl-2 and Bax, which are
important proteins in the regulation of apoptosis, and prognostic factors such as Ki-67 index
and survival time. In the retrospective study, 45 nodal, splenic and cutaneous lymphoma cases
were immunohistochemically labelled with CD3, CD4, CD79α, Pax5, Bcl-2, Bax and Ki-67
antibodies. Histological subclassifications of the cases whose immunophenotypes were
determined according to the revised REAL and updated Kiel systems were performed. Survival
times were recorded. Statistical analysis of the obtained data was done with Jamovi software,
version 2.3.21. In the study, Ki-67 proliferation marker was significantly higher as an indicator
that could be interpreted as a more aggressive course of especially nodal lymphomas in male
dogs (P=0.002); dogs with nodal lymphoma had significantly shorter survival times than splenic
and cutaneous cases (P=0.005); Pax 5 antibody is a strong (P<0.001) marker for detecting B
lymphomas; It has been concluded that the Kiel classification is a better system than the REAL
system in determining prognosis, and finally, the REAL system is useful. Still, the immune
panel should be broadened to identify subtypes.