Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

Lowery, Maeve; Wong, Winston; Jordan, Emmet; Lee, Jonathan; Kemel, Yelena; Vijai, Joseph; Mandelker, Diana; Zehir, Ahmet; Capanu, Marinela; Salo-Mullen, Erin; Arnold, Angela; Yu, Kenneth; Varghese, Anna; Kelsen, David; Brenner, Robin; Kaufmann, Erica; Ravichandran, Vignesh; Mukherjee, Semanti; Berger, Michael; Hyman, David; Klimstra, David; Abou-Alfa, Ghassan; Tjan, Catherine; Covington, Christina; Maynard, Hannah; Allen, Peter; Askan, GÖKÇE; Leach, Steven; Iacobuzio-Donahue, Christine; Robson, Mark; Offit, Kenneth; Stadler, Zsofia; O'Reilly, Eileen

doi:10.1093/jnci/djy024

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

Lowery M. A., Wong W., Jordan E. J., Lee J. W., Kemel Y., Vijai J., ...Daha Fazla

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, cilt.110, sa.10, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 110 Sayı: 10
Basım Tarihi: 2018
Doi Numarası: 10.1093/jnci/djy024
Dergi Adı: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine pancreatic neoplasms with genotype and phenotype association to facilitate identification of prognostic and/or predictive biomarkers and examine potential therapeutic implications.