Dispersive Solid Phase Extraction Using Folic Acid Coupled with a Modified Glassy Carbon Electrode for Electrochemical Sensing of Favipiravir in Urine and Water Samples

AVAN A. A., FİLİK H.

ANALYTICAL LETTERS, cilt.58, ss.3109-3132, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/00032719.2025.2454957
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.3109-3132
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

An acid-base reaction-based dispersive solid-phase extraction approach was developed for extracting favipiravir before its determination using an electrochemical sensor. The analyte was extracted from the samples using folic acid as an adsorbent. Cu@MoO2 nanoparticles were synthesized by chemically reducing CuMoO4 with NaBH4 and nitrogen-rich carbon (N-C) was prepared from safranine-O dyes. The characterized Cu@MoO2/N-C composites were used as an electrode modifier. The linear range and detection limit of the favipiravir were found to be 0.01-10 mu M and 0.7 nM, respectively. The developed system was applied to determine favipiravir in urine and water samples, with recoveries of 101-102% and 97-99%, respectively.