Akademik Veri Yönetim Sistemi
31st International Epilepsy Congress, İstanbul, Türkiye, 5 - 09 Eylül 2015, cilt.56, ss.7, (Özet Bildiri)
Purpose: Focal cortical dysplasia (FCD) is an abnormality of cortical
development that occurs during neuronal migration and often leads to
medically refractory seizures. The aim of this study was to examine the
compatibility of MRI, and PET findings in patients with epilepsy underwent surgery for refractory seizures and diagnosed to have FCD after
pathological examination.
Method: Cranial MRI, FDG-PET and histopathological findings of
patients who underwent surgery were included in the study. All data were
reviewed retrospectively and analysed according to the different
histopathological subgroups of FCD.
Results: There were 71 patients (38 females, 33 males); mean age at the
seizure onset was 8.5 years (1 months- 30 years), at surgery was
21.6 years (4 months-46 years) and mean duration of disease was
21.8 years (3 months-38 years). According to the ILAE histopathological classification, 21.2% (n = 20) patients were classified as type 1a;
19.7% (n = 14) as type 1b; 33.8% (n = 24) as type 2a and 18.3%
(n = 13) as type 2b. Localization of the lesions was as follows: temporal
35.2% (n = 25), frontal 46.4% (n = 33), parietal 16.9% (n = 12) and
occipital 1.4% (n = 1). FCD was visible in MRI of 76.05% (n = 54) of
patients, 29.6% (n = 16) of them had FCD type 1a; 14.8% (n = 8) type
1b; 33.3% (n = 18) type 2a and 22.2% type 2b. In 77.4% (n = 55)
patients there was FDG-PET hypometabolism where 24.4% (n = 14) of
them had temporal and FCD type 1a. In 59.1% (n = 42) patients both
MRI and PET was positive and 30.9% of them had type 1a and type 2a.
In. 14.08% (n = 10) of them PET positive MR negative and 40% (n = 4)
of them type 2a.The number of PET negative MRI positive was 11.2%
(n = 8).
Conclusion: EEG, MRI and 18F-PET have different importance and
should be evaluated in parallel before surgery