IL-6 receptor, IL-8 receptor and TNF-α238 (G/A) polymorphisms are not associated with Behçet's disease in patients of German or Turkish origin

Storz K., Loeffler J., Koch S., Vonthein R., Zouboulis C. C., Fresko İ., ...Daha Fazla

Clinical and Experimental Rheumatology, cilt.26, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2008
  • Dergi Adı: Clinical and Experimental Rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective. To assess the association of polymorphisms ofthe IL-6 receptor gene (+24013A/G:Ala31Ala; +48892 A/C: Asp358Ala), the IL-8 receptor gene (+ 2607G/C:Ser/Thr IL-8RA), and TNF-α 238 (G/A) single nucleotide polymorphism (SNP) with Behçet's disease in patients of German or Turkish origin. Methods. DNA was extracted from blood samples taken from patients in Germany (n=93) and Turkey (n=28), as well as from 51 German and 20 Turkish healthy controls. The polymorphisms were analysed by PCR with the LightCycler system. Results. No significant association was found between TNF-α 238, +2607 IL-8RA, +48892 IL-6R or +24013 IL-6R-polymorphisms and nationality or disease. Statistically there was no difference between the patients and controls (TNF-α 238:p = 0.86; +2607 IL-8RA:p=0.23; +48892 IL-6R: p=0.087; +24013 IL-6R: p = 0.80) nor between Germans and Turks (TNF-α 238: p=0.13; +2607 IL-8RA: p=0.68; +48892 IL-6R: p=0.32; +24013 IL-6R: p=0.65). Conclusion. The single nucleotide polymorphisms of the IL-6 and IL-8 receptor genes and the TNF-α gene analysed here do not appear to be associated with Behçet's disease. © Copyright Clinical and Experimental Rheumatology 2008.