Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.8, sa.3, ss.305-308, 1997 (Scopus, TRDizin)
To compare gastric pH control using intravenous famotidine as primed, continuous infusion versus intermittent infusion. In a prospective study, 20 patients with uncomplicated active peptic ulcer disease were randomly assigned to receive either famotidine 10 mg bolus followed 1.67 mg/h infusion or famotidine 20 mg intravenously every 12h. Intraluminal gastric pH was recorded continuously during the 48h period using an antimony pH electrode. In the first 24h, gastric pH was recorded without therapy and in the second 24h period, patients were randomised into two groups to receive either continuous infusion or bolus famotidine therapy. pH results of the groups were compared using student's t test. In the second 24h period, overall mean gastric pH was higher in the continuous infusion group (3.78±0.7 versus 2.41±0.6, p<0.01) and when gastric pH greater than 4 was used as an end point, the continuous infusion group exhibited better pH control (44.8±17.9%) versus 22.4±18.3% p<0.01). Also, percent of overall time above pH 5 was greater in the continuous infusion group 32.5 ± 12.7% versus 13.7 p 14.6% p<0.003). On the basis of both efficacy and cost, intermittent bolus injections should be replaced by continuous intravenous infusion in hospitalized patients requiring treatment with histamine H2 receptor antagonists.