Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?

Xu, Bin; Farhat, Nada; Barletta, Justine; Hung, Yin; de Biase, Dario; Casadei, Gian; Onenerk, AYŞE; Tuttle, R.; Roman, Benjamin; Katabi, Nora; Nose, Vania; Sadow, Peter; Tallini, Giovanni; Faquin, William; Ghossein, Ronald

doi:10.1007/s12020-017-1484-1

Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?

Xu B., Farhat N., Barletta J. A., Hung Y. P., de Biase D., Casadei G. P., ...Daha Fazla

ENDOCRINE, cilt.59, sa.1, ss.143-150, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 1
Basım Tarihi: 2018
Doi Numarası: 10.1007/s12020-017-1484-1
Dergi Adı: ENDOCRINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.143-150
Anahtar Kelimeler: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), Follicular variant, Papillary thyroid carcinoma, Papillary microcarcinoma, CANCER INCIDENCE, BRAF V600E, MICROCARCINOMA, IMPACT, EMPHASIS, MUTATION, TUMORS
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Objective In 2016, non-invasive, well-circumscribed and encapsulated, follicular variant of papillary thyroid carcinoma (NI-EFV PTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, the study cohort did not include subcentimeter tumors, i.e., papillary thyroid microcarcinoma (mPTC) with NI-EFV morphology, and such lesions are still regarded and staged by most pathologists as microcarcinomas. It is therefore crucial to evaluate the clinical outcome of subcentimeter NI-EFVs.