Fetal Fornix–Hippocampus Complex and Hippocampus Height Measurements Between 18 and 24 Weeks of Gestation and the Effect of Maternal Iron Deficiency Anemia
Journal of Clinical Ultrasound, cilt.53, sa.6, ss.1288-1295, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 6
- Basım Tarihi: 2025
- Doi Numarası: 10.1002/jcu.24008
- Dergi Adı: Journal of Clinical Ultrasound
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CINAHL
- Sayfa Sayıları: ss.1288-1295
- Anahtar Kelimeler: anemia, fetal, fornix, hippocampus, ultrasound
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Purpose: To construct nomograms for both sides of the fetal fornix–hippocampus complex (FHC) length and hippocampus height between 18 + 0 and 23 + 6 weeks of gestation using two-dimensional sonography. Additionally, we evaluated the effects of laterality, fetal sex, and maternal iron deficiency anemia on these measurements. Methods: This was a prospective cross-sectional study of 223 singleton pregnancies between 18 + 0 and 23 + 6 weeks of gestation. The FHC length and hippocampus height were measured on both sides in the parasagittal cranial plane of the fetus by 2D ultrasonography. Measurements from 30 women with iron deficiency anemia, out of 223 patients, were compared to those of normal controls. Results: Nomograms for FHC length and hippocampus height were constructed, showing a strong correlation with gestational age. No significant differences were found between the right and left side FHC lengths or hippocampus heights (p > 0.05), nor between male and female fetuses (p > 0.05). The FHC lengths (p > 0.05) and hippocampus heights (p > 0.05) of fetuses in anemic and non-anemic pregnancies also showed no significant differences. Conclusion: 2D ultrasound morphology of the fetal hippocampus and fornix during the second trimester is not significantly different between pregnancies with iron deficiency anemia and nonanemic women.