Akademik Veri Yönetim Sistemi
Cerrahpasa Tip Dergisi, cilt.27, sa.3, ss.159-166, 1996 (Scopus, TRDizin)
Background. The induction of ovulation in patients with PCO (polycystic ovary syndrome) is not always successful. It has been suggested that the administration of pure FSH preparations may be more fruitful in this respect because the endogenous levels of LH in these patients is high. This study compares the effects of human menopausal gonadotropin (hMG) and pure FSH therapy in PCO patients. Design. 20 patients who were diagnosed as having PCO (mean age: 28.2 ± 4.52) were recruited. 10 patients received pure FSH (mean age 26.6 ± 4.05) and 10 patients (mean age 29.8 ± 5.01) took hMG after their hypothalamo-pituitary axis was desensitized with 'short protocol' GnRH analogue. (buserelin acetate) The levels of E2, LH, FSH, T, 4A, DHE As and insulin, the number of developing follicles, follicle diameter, number of oocytes, the total number of vials administered, endometrial development and cleavage rates were evaluated in both groups. Results and Conclusion. The increase in DHEAs in the pure FSH group was higher than that observed in the hMG group (p<0.05). The number of mature oocytes and pregnancies were higher in the hMG group (p<0.05). However, one patient in this group developed mild ovarian hyperstimulation syndrome (OHSS). The other parameters measured did not differ between the groups. It was concluded that high levels of follicular testosterone does not cause follicular atresia.