Akademik Veri Yönetim Sistemi
Turk Onkoloji Dergisi, cilt.39, sa.1, ss.50-56, 2024 (ESCI, Scopus, TRDizin)
OBJECTIVE Nasopharyngeal cancer (NPC) in childhood is rare. In this study, we retrospectively report the results of adolescent and childhood NPC patients treated with different doses of intensity-modulated radiation therapy (IMRT) and 3D-conformal radiotherapy (RT) (3D-RT). METHODS Between 2007 and 2020, 20 patients were included in our study, 18 of whom received induction chemotherapy before chemoradiotherapy (CRT) (n=16) or RT (n=2). High-risk planning target volumes of 61.2 Gy (complete or good partial response) and 63–70 Gy (partial response) included the primary tumor and metastatic lymph nodes. Survival analyses were made using the Kaplan–Meier method. RESULTS The median follow-up time was 107 months (range: 6–168). The median age was 16 years (range 11–22). All patients had a complete response after CRT. The 5-year local control, disease-free survival, and overall survival were 100%. One patient developed distant metastasis (bone) at 62 months of treatment. There were no grade 4 acute side effects. Acute and late toxicity were observed lower in patients treated by dose reduction with IMRT. CONCLUSION In our study, over 60% of patients were treated with IMRT and dose reduction. Although lower-dose RT was administered, local-regional control was excellent, and the incidence rate of side effects was low.