The effect of LKB1 on the PI3K/Akt pathway activation in association with PTEN and PIK3CA in HNC.

Ekizoglu, SEDA; Dogan, S.; Ulker, D.; Seven, D.; Gozen, EMİNE; Karaman, EMİN; Buyru, AYŞE

doi:10.1111/coa.12427

The effect of LKB1 on the PI3K/Akt pathway activation in association with PTEN and PIK3CA in HNC.

Ekizoglu S., Dogan S., Ulker D., Seven D., Gozen E. D., Karaman E., ...Daha Fazla

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, cilt.40, sa.6, ss.622-8, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 40 Sayı: 6
Basım Tarihi: 2015
Doi Numarası: 10.1111/coa.12427
Dergi Adı: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.622-8
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Objective: PI3K/Akt signalling pathway is frequently activated in several types of cancer. However, activator molecules have not been analysed systematically in HNSCC. The aim of this study was to investigate upstream activators and inhibitors of this pathway.