Erythroid microRNA and oxidant status alterations in l-thyroxine-induced hyperthyroid rats: effects of selenium supplementation

Bahtiyar N., Yoldas A., Abbak Y., Dariyerli N., Toplan S.

MINERVA ENDOCRINOLOGICA, cilt.46, sa.1, ss.107-115, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.23736/s2724-6507.20.03154-5
  • Dergi Adı: MINERVA ENDOCRINOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.107-115
  • Anahtar Kelimeler: Hyperthyroidism, Oxidants, Erythrocytes, Selenium, MicroRNAs
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

BACKGROUND: Hypermetabolic state in hyperthyroidism causes oxidative stress. Erythrocytes are the cells that are involved in oxidant equilibrium in an organism and contain microRNA (miRNA). Selenium, which is an essential element for an organism, has antioxidant properties. The present study was aimed at investigating the effects of selenium supplementation in hyperthyroidism, on pro- and antioxidant enzymes, and miRNA (miR-144 and miR-451) expressions in the erythrocytes.