The Influence of Vitamin D Treatment on the Inducible Nitric Oxide Synthase (INOS) Expression in Primary Hippocampal Neurons.

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Dursun E., Gezen-Ak D., Yilmazer S.

Noro psikiyatri arsivi, cilt.51, sa.2, ss.163-168, 2014 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.4274/npa.y7089
  • Dergi Adı: Noro psikiyatri arsivi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.163-168
  • Anahtar Kelimeler: Alzheimer's disease, vitamin D, inducible nitric oxide synthase (iNOS), primary hippocampal neuron culture, D-RECEPTOR GENE, ALZHEIMERS-DISEASE, AMYLOID-BETA, INFLAMMATORY NEURODEGENERATION, D DEFICIENCY, ASSOCIATION, BRAIN, POLYMORPHISM, COMBINATION, PERFORMANCE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Introduction: Neurodegeneration is a process that is characterized by the loss of neuronal structure and function and eventually ends with neuronal death. An elevated level of inducible nitric oxide synthase (iNOS) is suggested to accompany this process by inducing oxidative and nitrosative damage. Vitamin D is reported to protect glial cells against neurotoxicity via suppressing iNOS synthesis. Though there was no data about whether iNOS is regulated by vitamin D in hippocampal neurons. In this study our aim was to determine any alteration in iNOS expression of hippocampal neurons in response to vitamin D treatment.