The Influence of Vitamin D Treatment on the Inducible Nitric Oxide Synthase (INOS) Expression in Primary Hippocampal Neurons.

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Dursun E., Gezen-Ak D., Yilmazer S.

Noro psikiyatri arsivi, vol.51, no.2, pp.163-168, 2014 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.4274/npa.y7089
  • Journal Name: Noro psikiyatri arsivi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.163-168
  • Keywords: Alzheimer's disease, vitamin D, inducible nitric oxide synthase (iNOS), primary hippocampal neuron culture, D-RECEPTOR GENE, ALZHEIMERS-DISEASE, AMYLOID-BETA, INFLAMMATORY NEURODEGENERATION, D DEFICIENCY, ASSOCIATION, BRAIN, POLYMORPHISM, COMBINATION, PERFORMANCE
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Introduction: Neurodegeneration is a process that is characterized by the loss of neuronal structure and function and eventually ends with neuronal death. An elevated level of inducible nitric oxide synthase (iNOS) is suggested to accompany this process by inducing oxidative and nitrosative damage. Vitamin D is reported to protect glial cells against neurotoxicity via suppressing iNOS synthesis. Though there was no data about whether iNOS is regulated by vitamin D in hippocampal neurons. In this study our aim was to determine any alteration in iNOS expression of hippocampal neurons in response to vitamin D treatment.