Research Information System
in: Phytochemical Potentials for Dermatological Applications, Amit Kumar Mandal,Florina Miere (Groza),Simona Ioana Vicas, Editor, Crc Press-Taylor & Francis Group, London, pp.76-103, 2025
Human skin, the body’s largest organ, supports a complex ecosystem of microorganisms including bacteria, fungi, viruses, and mites, collectively forming the skin microbiome. This microbiome is influenced by factors such as age, sex, hygiene, and pH, resulting in distinct microbial communities in different skin regions. Maintaining a balanced microbiome is essential for skin health, as imbalances can lead to disorders. The skin acts as a physical, chemical, and immunological barrier, with commensal microbiota contributing to its functions and preventing pathogenic colonization through dynamic interactions with the immune system. Atopic dermatitis (AD) and psoriasis are chronic skin conditions linked to disruptions in the skin microbiome. AD is marked by itchy, dry patches and an increased presence of Staphylococcus aureus, which disrupts the immune response and skin barrier