Akademik Veri Yönetim Sistemi
Agri Dergisi, cilt.8, sa.2, ss.26-32, 1996 (Scopus)
The benzodiazepine binding sites are located in the dorsal horn where this place have an important role on processing noxious information. The purpose of this study is to evaluate the effects of midazolam on antinociception with intramuscular and epidural routes. Sixteen New Zealand albino rabbits were studied. Invasive blood pressure, heart rate, oxygen saturation monitored. Pain models with squeezing tail (using a 4 mode clamp); somatic pain 1 (SA1), electrical skin stimulation on L7-1 and T4 levels; (SA2) and colon stretching by filling a foley catheter balloon with saline; visceral pain (VA) created and pelvic withdrawal thresholds recorded. Eight rabbits Group (I) received intramuscular and 8 rabbits Group (II) received epidural 250 μg/kg midazolam at equivalent doses. Blood pressures, heart rate and SpO2 was stable throughout the study in both groups. Sedation and pelvic withdrawal response to noxious stimulation was observed 10 min after IM administration and lasted in two hours. The pain threshold levels increased starting at 5th minute and decreased progressively since 60 min in all members of Group II. The significance of sedation and antinociceptive effects between groups were p=0.00008. It is concluded that epidural midazolam has antinociceptive effects on visceral and somatic pain stimulus in rabbits.