Akademik Veri Yönetim Sistemi
Jinekoloji ve Obstetrik Dergisi, cilt.9, sa.1, ss.13-19, 1995 (Scopus)
OBJECTIVE: To evaluate the platelet aggregation in severe preeclampsia. STUDY DESIGN: Twenty severe preeclamptic and 14 normotensive pregnant women were randomly selected in 32-37 weeks' gestation among the pregnant women who had applied to Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, Istanbul University. The platelet aggregation tests with ADP, adrenaline and collagen were comparatively performed. Threshold values of ADP and adrenaline inducing secondary wave aggregation in platelets were determined. ADP and adrenaline were administered in doses of 0.25, 0.50, 1.00 and 2.00 μM and 0.5 μg/ml collagen was administered in platelet rich plasma derived from cases. Aggregation was measured by optical aggregometer. Percentage of cases which aggregated with ADP and adrenaline were plotted against the graph in relation to the aggregating substance doses. RESULTS: Results have revealed that the severe preeclamptic patients required higher ADP and adrenaline doses to induce secondary wave aggregation than normotensive pregnants. Difference of aggregation has reached the maximum with 0.5 μM ADP (p < 0.05). Significant differences were observed in 1.00 μM ADP and 0.5 μg/ml collagen at the level of 0.1, however adrenaline never caused significant difference in any dose used. CONCLUSION: This study clearly showed that severe preeclamptic patients are desensitized to aggregating agents. Insufficient storage of proaggregant substances in platelet pool is the probable explanation and platelets might have an active role in the pathogenesis of preeclampsia.