Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Zhang, Qian; Matuozzo, Daniela; Le Pen, Jeremie; Lee, Danyel; Moens, Leen; Asano, Takaki; Bohlen, Jonathan; Liu, Zhiyong; Moncada-Velez, Marcela; Kendir-Demirkol, Yasemin; Jing, Huie; Bizien, Lucy; Marchal, Astrid; Abolhassani, Hassan; Delafontaine, Selket; Bucciol, Giorgia; BAYHAN, GÜLSÜM; KELEŞ, SEVGİ; KIYKIM, AYÇA; Hancerli, Selda; Haerynck, Filomeen; Florkin, Benoit; Hatipoglu, Nevin; ÖZÇELİK, TAYFUN; Morelle, Guillaume; Zatz, Mayana; Ng, Lisa; Lye, David; Young, Barnaby; Leo, Yee-Sin; Dalgard, Clifton; Lifton, Richard; Renia, Laurent; Meyts, Isabelle; Jouanguy, Emmanuelle; Hammarstrom, Lennart; Pan-Hammarstrom, Qiang; Boisson, Bertrand; Bastard, Paul; Su, Helen; Boisson-Dupuis, Stephanie; Abel, Laurent; Rice, Charles; Zhang, Shen-Ying; Cobat, Aurelie; Casanova, Jean-Laurent

doi:10.1084/jem.20220131

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Zhang Q., Matuozzo D., Le Pen J., Lee D., Moens L., Asano T., ...Daha Fazla

JOURNAL OF EXPERIMENTAL MEDICINE, cilt.219, sa.8, 2022 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 219 Sayı: 8
Basım Tarihi: 2022
Doi Numarası: 10.1084/jem.20220131
Dergi Adı: JOURNAL OF EXPERIMENTAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

In an international cohort of 112 children hospitalized for moderate to critical COVID-19 pneumonia, we identified 12 children with one of four known recessive inborn errors of type I interferon immunity: X-linked TLR7 and autosomal IFNAR1, STAT2, and TYK2 deficiencies.