High-dose piracetam is effective on cerebellar ataxia in a patient with cerebellar cortical atrophy

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Vural M., Ozekmekci S., Apaydin H., Altinel A.

MOVEMENT DISORDERS, cilt.18, sa.4, ss.457-459, 2003 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/mds.10364
  • Dergi Adı: MOVEMENT DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.457-459
  • Anahtar Kelimeler: piracetam, cerebellar ataxia, tandem gait, treatment of ataxia, AMANTADINE HYDROCHLORIDE, BUSPIRONE, MYOCLONUS, DISEASE, AGONIST, TRIAL
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

We describe a patient with cerebellar ataxia of degenerative nature who was administered high-dose piracetam in a single-blind trial. Piracetam was demonstrated to be highly effective on tandem gait and gait ataxia in daily doses of 60 g. We suggest piracetam has a potential anti-ataxic effect in human cerebellar ataxia when used in considerably higher doses than those indicated for other purposes. (C) 2003 Movement Disorder Society.

We report on a patient with spontaneous and stimulus-

sensitive myoclonic jerks and dystonia of the right leg that

had been present since infancy. Magnetic resonance imaging

showed a linear area of gliosis confined to the left posterolateral

putamen. This is the first report of focal myoclonus-dystonia of

the lower limb secondary to a putaminal lesion.