Akademik Veri Yönetim Sistemi
Cerrahpasa Tip Fakultesi Dergisi, cilt.25, sa.3, ss.369-376, 1994 (Scopus)
Positive effect of locally applied collagen implants on wound healing was supported by many clinical and experimental studies. Local use of collagen together with heparin on wounds is encountered in some studies. In this experimental model, we aimed to investigate the probable role of systemically given standard heparin on the effects of collagen on wound healing. Twenty-one rats, divided to three main groups, were used in this study. Granulation tissue samples were taken from wounds of each rat at the 7th and 14th days and measurements of hydroxyproline levels and histopathologic examinations were done. Heparin was given subcutaneously at the dose of 1 IU/g (body weight), started 12 hours before operation and continued on until 7 days postoperatively with 24 h intervals. There were no statistical differences between the Hydroxyproline value group was % 9.2 higher according to controls and was % 13.6 higher to heparin-collagen groups. According to these evidences, we thought that heparin may have a negative effect on collagen synthesis in wound. Evidential increase of neovascularisation at the 7th and 14th day in heparin group were observed (p < 0.05). Histopathologic observations were given according-to the pathologists comments. We observed that lyophilized collagen have beneficial effect on wound healing. Positive effect of heparin on neovascularisation were found in our-experimental study as well. Because of enhancing effect on neovascularisation, we presumed that heparin can also play a positive role on wound healing. This effect of heparin must be evaluated by other experimental and clinical studies.