Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion
POLISH JOURNAL OF PATHOLOGY, cilt.74, sa.4, ss.282-285, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 74 Sayı: 4
- Basım Tarihi: 2023
- Doi Numarası: 10.5114/pjp.2023.134321
- Dergi Adı: POLISH JOURNAL OF PATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Directory of Open Access Journals
- Sayfa Sayıları: ss.282-285
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Biphenotypic sinonasal sarcoma (BSNS), previously known as low-grade sinonasal sarcoma, is a rare tumour of the sinonasal tract, first described in 2012. It involves both myogenic and neural differentiation and is characterized by PAX3 rearrangement. MAML3 is the most frequent fusion partner of PAX3; however, its partner remains unidentified in a subset of cases. These tumours have significant local recurrence rates but lack metastatic potential. Here, we report a case of BSNS with PAX3/ FOXO1 fusion and discuss its clinicopathological features and differential diagnosis.