Akademik Veri Yönetim Sistemi
Cocuk Enfeksiyon Dergisi, cilt.14, sa.2, 2020 (ESCI, Scopus, TRDizin)
© 2020 by Pediatric Infectious Diseases and Immunization Society. Available online at www.cocukenfeksiyon.org.Objective: Early diagnosis of sepsis is important for effective treatment and improved prognosis. C-reactive protein (CRP) and procalcitonin (PCT) are the most commonly used biomarkers for sepsis. However, their routine usage is not cost-effective. Complete Blood Count (CBC) parameters including red cell distribution width (RDW), neutrophil to lympho-cyte ratios (NLR), platelet to lymphocyte ratios (PLR), mean platelet volume (MPV), and hemoglobin are simple and easily calculated. The aim of this study was to determine the CBC parameters in patients with sepsis on admission and compare with those of the control group. Material and Methods: The medical records of 115 eligible patients (68 sepsis, 47 control patients) who were hospitalized in PICU between January 2014 and March 2019 were retrospectively investigated. Demo-graphic, prognostic and laboratory findings of the patients admitted with sepsis were compared with those of the control patients. Results: Sixty-eight (59.1%) of the patients were admitted with sepsis, severe sepsis or septic shock. In sepsis patients, CRP (p< 0.001), leukocyte count (p= 0.004), MPV (p< 0.001), RDW (p< 0.001) were higher and platelet count (p= 0.016) was lower than the control group, the difference was statistically significant. Analysis of ROC curves showed that CRP, at a cut off value 0.66 mg/dL, had a sensitivity of 82.4% and a specificity of 70.2%. RDW showed 76.5% sensitivity and 76.6% specificity (cut off: 14.55%); hemoglobin showed 83.0% sensitivity and 72.3% specificity (cut off: 10.9 g/dL). Correlation analysis showed positive correlation between sepsis and CRP (r= 0.627, p< 0.001) and RDW (r= 0.585, p< 0.001), and a negative correlation with hemoglobin (r=-0.562, p< 0.001). In logistic regres-sion analysis, each numerical increase of RDW increases the probability of having sepsis by 2.094 fold. Conclusion: Admission RDW, MPV, platelet, and hemoglobin values are related with sepsis in the PICU. These parameters are cost effective, use-ful, and easily accessible tests for diagnosing sepsis in critically-ill children. However, RDW alone may not provide sufficient evidence for the diagnosis of sepsis.