Akademik Veri Yönetim Sistemi
Turk Pediatri Arsivi, cilt.48, sa.3, ss.204-209, 2013 (SCI-Expanded, ESCI, Scopus, TRDizin)
Aim: X linked agammaglobulinemia (XLA) and selective IgA deficiency are predominantly antibody deficiency syndromes. Recurrent sinopulmonary infections are common problems observed in both diseases. IgG, IgM and salivary IgA which are present especially in gingival crevice are involved in the defense of the oral cavity. The aim of our study was to investigate oral mucosa, dental health and microfloral variation in selective IgA deficiency and XLA patients by comparison with the healthy group. Material and Method: We reviewed 18 selective IgA deficient subjects (12 (66,7%) boys and 6 (33,3%) girls), 12 patients with Bruton's disease and 31 age-matched healthy children aged 2-18 years with normal leucocyte and immunoglobuline levels. Oral mucosal investigation, dental caries, plaque and gingival indices were assessed and all patients were evaluated for S.mutans, Lactobacillus and yeast colonization in İstanbul University Faculty of Dentistry. Results: No significant differences were detected between the groups in terms of high S. mutants level and other parameters. Significantly higher lactobacillus and yeast levels were found in XLA patients compared to the selective IgA deficient subjects and healthy group, respectively. High lactobacillus and yeast levels were correlated with frequent consumption of starch-rich food. Presence of dental caries was correlated with high plaque and gingival indices. Conclusions: The higher frequency of Lactobacillus and yeast colonization in XLA patients indicates that antibodies have a major influence on oral microbiota and antibacterial defense. The similar frequency in dental caries and oral mucosal lesions among the groups suggests the importance of neutrophils and antibacterial substances taking part in innate immunity.