Significance of catechol-O-methyltransferase gene polymorphism in myofacial pain syndrome
PAIN CLINIC, cilt.15, sa.3, ss.309-313, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 3
- Basım Tarihi: 2003
- Doi Numarası: 10.1163/156856903767650844
- Dergi Adı: PAIN CLINIC
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.309-313
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
The objective was to investigate possible association of the catechol o-methyl transferase (COMT) gene polymorphisms with myofacial pain syndrome (MFPS). The polymorphism of the COMT gene was compared between 49 patients with MFPS and 113 control subjects. Relationship between COMT polymorphism and psychiatric status of the patients was also assessed using SCL-90-R, BDS, and STAI-I and II tests. A PCR-based restriction fragment length polymorphism assay was used to detect G A transition at position 1947 in COMT. There was no relationship between MFPS and COMT polymorphism (p > 0.05). The patients who had MFPS without any temporomandibular joint problem had significantly higher expression of LL genotype when compared to those with joint problems (p < 0.05). There was no relationship between nocturnal bruxism and COMT polymorphism (p > 0.05). In conclusion, MFPS is not related to COMT polymorphism. COMT polymorphism is not associated with the psychiatric status of the patients. COMT polymorphism may be important for dose adjustment when the use of catechol drugs is anticipated.