Cranial nerve injury as an initial sign of wegener granulomatosis: Misdiagnosis and fatal course in two cases
Turkish Nephrology, Dialysis and Transplantation Journal, cilt.23, sa.2, ss.164-168, 2014 (SCI-Expanded, ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 2
- Basım Tarihi: 2014
- Doi Numarası: 10.5262/tndt.2014.1002.18
- Dergi Adı: Turkish Nephrology, Dialysis and Transplantation Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.164-168
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Highest prevalence of all antineutrophil cytoplasmic antibody associated systemic vasculitides is the Wegener granulomatosis, and it's typically characterized by a necrotizing granulomatous vasculitis of the respiratory tracts, kidneys, and skin. Neurologic involvement in Wegener granulomatosis ranges from 22% to 54%, but central nervous system involvement is from 2% to 8%. Cranial nerve involvement as an initial sign with concomitant systemic disease is extremely rare. Involvement of one or more cranial nerves is generally a seemingly isolated finding in Wegener granulomatosis. We present WG cases that presented with treatment-resistant cranial nerve involvement and acute fatal pulmonary-renal syndrome.