SARS-CoV-2 IgG Antibody Levels After Inactivated Vaccine (CoronaVac) among Elderly

Dinc H. O., Balkan I. I., Budak B., Demirci M., Ozbey D., Karaali R., ...Daha Fazla

Infectious Diseases and Clinical Microbiology, cilt.4, sa.2, ss.129-132, 2022 (ESCI, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.36519/idcm.2022.115
  • Dergi Adı: Infectious Diseases and Clinical Microbiology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.129-132
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

We aimed to describe the antibody response against SARS-CoV-2 after inactivated COVID-19 vaccine in elderly individuals. SARS-CoV-2 IgG levels were measured in the blood samples of 126 volunteers over the age of 60. The antibody positivity rate was 42.8% after the first dose and 96.8% after the second dose of the vaccine. The median antibody titers after two vaccine doses were 561.3AU/mL and 43AU/mL, respectively(p<0.001). After vaccination, 22.2% of the participants had antibodies equivalent to 1:80 dilutions in plaque reduction neutralization test (PNRT). We believe that the booster dose is needed to continue the protective immune response in especially elderly groups.