Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Sahin, Ziver; Bicakcigil, Muge; AKSU, KENAN; Kamali, Sevil; Akar, Servet; ÖNEN, FATOŞ; KARADAĞ, ÖMER; Ozbalkan, Zeynep; Ates, Askin; Ozer, Huseyin; Yilmaz, Vuslat; Seyahi, EMİRE; Ozturk, Mehmet; ÇEFLE, AYŞE; Cobankara, Veli; Onat, A.; Tunc, Ercan; DÜZGÜN, NURŞEN; Aydin, Sibel; Yilmaz, Neslihan; Fresko, İZZET; Karaaslan, Yasar; KİRAZ, SEDAT; AKKOÇ, NURULLAH; Inanc, Murat; KESER, GÖKHAN; Uyar, F.; Direskeneli, Haner; Saruhan-Direskeneli, Guher

doi:10.1186/ar3730

Takayasu's arteritis is associated with HLA-B52, but not with HLA-B51, in Turkey

Sahin Z., Bicakcigil M., AKSU K., Kamali S., Akar S., ÖNEN F., ...More

ARTHRITIS RESEARCH & THERAPY, vol.14, no.1, 2012 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 14 Issue: 1
Publication Date: 2012
Doi Number: 10.1186/ar3730
Journal Name: ARTHRITIS RESEARCH & THERAPY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Open Archive Collection: AVESIS Open Access Collection
Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Introduction: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Beh et's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B* 52 as susceptibility and severity factors.