The effect of clarithromycin+amoxicillin treatment on oxidative DNA damage in helicobacter pylori infected cases Helicobacter pylori ile enfekte vakalarda clarithromycin+amoxicillin tedavisinin oksidatif DNA hasan üzerine etkisi

Dinçer Y., Akçay T., Saygili E. I., Ersoy E. Y., Tortum O.

UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.17, sa.4, ss.204-208, 2007 (SCI-Expanded, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2007
  • Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.204-208
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Epidemiological studies revealed increased gastric cancer risk in helicobacter pylori-infected cases and Helicobacter pylori-mediated oxidative DNA damage is suggested as responsible factor. In order to examine the effect of clarithromycin+amoxicillin treatment on oxidative DNA damage in helicobacter pylori-infected cases, DNA damage in the basis of frequency of DNA strand breaks and formamidopyrimidine DNA glycosylase (fpg)-sensitive sites were determined before and after two weeks of treatment with clarithromycin (1 g/day) and amoxicillin (1 g/day). The frequency of fpg-sensitive sites determined by the comet assay was found to be decreased after the treatment (p<0.001) but frequency of DNA strand breaks was unchanged. Frequency of fpg-sensitive sites was found to be positively correlated with age (r: 0.59; p<0.05). Our data suggested that treatment of helicobacter pylori by clarithromycin +amoxicillin may prevent the helicobacter pylori-mediated gastric cancer risk by decreasing oxidative DNA damage in helicobacter pylori infected patients.