Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability

Petain S., KASNAK G., Firatli E., Tervahartiala T., Gursoy U. K., Sorsa T.

ACTA HISTOCHEMICA, vol.123, no.6, 2021 (SCI-Expanded, AHCI, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1016/j.acthis.2021.151767
  • Journal Name: ACTA HISTOCHEMICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Arts and Humanities Citation Index (AHCI), Scopus, Academic Search Premier, Aerospace Database, Communication Abstracts, EMBASE, MEDLINE, Metadex, Civil Engineering Abstracts
  • Keywords: MMP-8, collagenase-2, Td-CTLP, Treponema denticola, Periodontitis, Peri-implantitis, CONSENSUS REPORT, BIOMARKERS, PROTEINASE, EXPRESSION, DISEASES, CELLS
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Background and Aims: Chymotrypsin-like-proteinase of Treponema denticola (Td-CTLP) can stimulate the protein expression and activation of matrix metalloproteinase (MMP)-8 (or collagenase-2), a potent tissue destructive enzyme from gingival cells in vitro. The aims of this study were 1) to demonstrate the proMMP-8 (or latent MMP-8) activation by Td-CTLP in vitro and 2) to detect Td-CTLP and MMP-8 protein levels in the tissue samples of peri-implantitis and periodontitis patients.