Biospectroscopy screening and molecular fingerprinting of gastric cancer cases from biofluids by vibrational spectroscopy allied with chemometrics

Tugrul F., Akin Geyik G., Peker Cengiz B., Yalinbas Kaya B., KARUK ELMAS Ş. N., Yilmaz I., ...Daha Fazla

SCIENTIFIC REPORTS, cilt.15, sa.1, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1038/s41598-025-09912-0
  • Dergi Adı: SCIENTIFIC REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, MEDLINE, Directory of Open Access Journals
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

The present study aims to develop a new molecular diagnostic modality based upon mid-infrared (mid-IR) spectroscopy allied with chemometrics for the diagnosis of gastric cancer (GC) from diverse biofluids. The characterization over the spectral data specified the changes at molecular level caused from the synthesis of main biomolecules like lipids, proteins and carbohydrates was performed. The spectral data from the cancer and their control cases were analyzed by practicing the supervised and unsupervised chemometrics analysis including PCA, SIMCA, LDA and HCA. The results indicated that remarkable changes were occurred in the content of biomolecules for GC cases due to energy necessities. 100% of the cancer cases from blood serum, blood plasma and saliva biofluids were successfully discriminated from their control specimens by LDA. Consequently, this research established the potential of mid-IR spectroscopy allied with chemometrics for evaluating biochemical changes of GC cases with high sensitivity and precision.