Association of CYP2D6*4 gene polymorphism with early papillary thyroid carcinoma

Aday A. D., ÖZTÜRK T., Teker B. A., Aksoy F., Aydogan H. Y., Ozturk O., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.46, sa.4, ss.455-460, 2021 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/tjb-2020-0103
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.455-460
  • Anahtar Kelimeler: CYP2D6, papillary thyroid carcinoma, polymorphism, rs3892097, xenobiotic, CYP2D6 GENE, SUSCEPTIBILITY, CYTOCHROME-P450, IDENTIFICATION, MARKERS, DEFECT, GSTM1, GSTT1
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objectives: CYP2D6 is highly polymorphic and a common variant CYP2D6*4 results in the generation of poor metabolizer enzyme. The CYP2D6*4 variant has been associated with altered susceptibility to several cancers. The aim of the present case-control study aims to investigate the association between CYP2D6*4 polymorphism and the risk of papillary thyroid carcinoma (PTC).