Increased DNA-Glycation in Type 2 Diabetic Patients: The Effect of Thiamine and Pyridoxine Therapy

Polizzi F. C., Andican G., Cetin E., Civelek S., Yumuk V. D., Burcak G.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, cilt.120, sa.6, ss.329-334, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1055/s-0031-1298016
  • Dergi Adı: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.329-334
  • Anahtar Kelimeler: diabetes, diabetic nephropathy, DNA glycation, vitamin B-1, vitamin B-6, GLYCOSYLATION END-PRODUCTS, VEIN ENDOTHELIAL-CELLS, HIGH GLUCOSE, IN-VITRO, NONENZYMATIC GLYCATION, ALDEHYDE REDUCTASE, REDUCING SUGARS, METHYLGLYOXAL, DAMAGE, PYRIDOXAMINE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: It is well known that advanced glycation plays an important role in the progression of diabetic complications. Although several studies have been done on protein glycation, studies related to DNA glycation is limited. The aim of this study is primarily to investigate DNA glycation in diabetes mellitus and secondarily to observe the effects of vitamins B-1 and B-6.