Diagnostic capabilities of mri versus18 F FDG PET-CT in postoperative patients with thyroglobulin positive, 131 I-negative local recurrent or metastatic thyroid cancer

Samanci C., Onal Y., Sager S., Asa S., Ustabasioglu F. E., Alis D., ...Daha Fazla

Current Medical Imaging, cilt.15, sa.10, ss.956-964, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 10
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1573405614666180718124739
  • Dergi Adı: Current Medical Imaging
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.956-964
  • Anahtar Kelimeler: Magnetic resonance imaging, F-18-fluorodeoxyglucose positron emission tomography, thyroid cancer, metastasis, positive predictive value, sensitivity, EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY, WHOLE-BODY SCINTIGRAPHY, CONTRAST-ENHANCED SUBTRACTION, SQUAMOUS-CELL CARCINOMA, DIFFUSION-WEIGHTED MRI, CERVICAL LYMPH-NODES, FOLLOW-UP, ELEVATED THYROGLOBULIN, NECK-CANCER, HEAD
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

© 2019 Bentham Science Publishers.Background: The detection of recurrence or metastasis might be challenging in patients, who underwent total thyroidectomy and radioactive iodine therapy for Differentiated Thyroid Carcinoma (DTC), with increased serum Thyroglobulin (Tg) levels and negative131 I whole body scan (131 I-WBS) results. Aims: The purpose of this study was to compare the ability of Magnetic Resonance Imaging (MRI) and18 F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18 F FDG PET-CT) to detect recurrence or cervical and upper mediastinal metastases in postoperative DTC patients who had negative131 I-WBS despite elevated serum Tg levels. Study Design: This study has a retrospective study design. Methods: We evaluated cervical and upper mediastinal MRI and18 F FDG PET-CT of 32 postoperative patients with DTC (26 patients with papillary thyroid carcinoma and 6 patients with follicu-lar thyroid carcinoma). Results: We evaluated 44 lesions in 32 patients. For all lesions, the Positive Predictive Value, (PPV) Negative Predictive Value (NPV), sensitivity, specificity, and accuracy of MRI were 81.4%, 76.4%, 84.6%, 72.2%, and 79.5% respectively. The PPV, NPV, sensitivity, specificity, and accuracy of18 F FDG PET-CT were 100.0%, 85.7%, 88.4%, 100.0%, and 93.1%, respectively. Conclusion: Although we could not replace18 F FDG PET-CT, MRI might be used as an adjunct to18 F FDG PET-CT for the evaluation of recurrent or cervical and upper mediastinal metastatic thyroid cancers; however, MRI is inadequate for the detection of metastases in small lymph nodes.