The evaluation of biological activities of N-, S-substituted polyhalogenated butadiene compounds
Research Journal of Pharmaceutical, Biological and Chemical Sciences, cilt.2, sa.3, ss.661-669, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 3
- Basım Tarihi: 2011
- Dergi Adı: Research Journal of Pharmaceutical, Biological and Chemical Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.661-669
- Anahtar Kelimeler: Antifungal activity, Antimicrobial activity, N,S-substituted nitrodiene, Piperazine derivatives, Thiomorpholine
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
A series of N-(diphenylmethyl)piperazine, thiomorpholine and alkylthio substituted nitro-1,3-butadiene compounds have been synthesized and tested for their antimicrobial, antifungal activities and for evaluation of growth regulative action. Compounds 2b, 2c, 2d in 0.5% concentration showed moderate activity against Myc.luteum and C.tenuis. Biological activity prediction was carried out by using the computer program PASS C&T which indicated the necessity of further investigation of synthesized compounds in this order.