Hyperpigmentation due to pyrimethamine use

Ozturk R., Engin A., Ozaras R., Mert A., Tabak F., Aktuglu Y.

JOURNAL OF DERMATOLOGY, cilt.29, sa.7, ss.443-445, 2002 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1111/j.1346-8138.2002.tb00303.x
  • Dergi Adı: JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.443-445
  • Anahtar Kelimeler: pyrimethamine, hyperpigmentation, toxoplasmosis, MALARIA, SULFADOXINE, CHILDREN
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Pyrimethamine is used for the treatment of tuxoplasmosis and the prophylaxis of malaria. Among the well-documented side effects are megaloblastic anemia, leukopenia, thrombopenia, rash, vomiting, and diarrhea. Hyperpigmentation is a very rare side effect. In some patients, associated HIV infection makes it difficult to distinguish the reasons for the etiology. We herein describe an HIV-negative patient who developed hyperpigmentation after pyrimethamine use.