Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients.

Creative Commons License

Kuru D., Arguden Y. T., Ar M. C., Cirakoglu A., Ongoren S., Yilmaz S., ...Daha Fazla

Turkish journal of haematology : official journal of Turkish Society of Haematology, cilt.28, sa.3, ss.186-92, 2011 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.52
  • Dergi Adı: Turkish journal of haematology : official journal of Turkish Society of Haematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.186-92
  • Anahtar Kelimeler: Chronic myeloid leukemia (CML), variant Ph chromosome, cytogenetics, fluorescence in situ hybridization (FISH), IN-SITU HYBRIDIZATION, CHRONIC MYELOGENOUS LEUKEMIA, CHROMOSOME TRANSLOCATIONS, FUSION, REARRANGEMENTS, DELETIONS, FISH, BCR
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11) translocation, is observed in similar to 90% of patients with chronic myeloid leukemia (CML). Variant Ph translocations are observed in 5%-40% of CML patients. In variant translocations 3 and possibly more chromosomes are involved. Herein we report 6 CML patients with variant Ph translocations.