RELATIONSHIPOF CIRCULATING IRISIN WITH BODY COMPOSITION IN CHILDREN WITH CHRONIC KIDNEY

Ceyhun E., Saygılı S. K., Devran S., Aydın R., Demirtaş K. C., Çelen Ş., ...Daha Fazla

54th Annual Scientific Meeting of ESPN, Ljubljana, Slovenya, 23 - 25 Haziran 2022, ss.2838, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Ljubljana
  • Basıldığı Ülke: Slovenya
  • Sayfa Sayıları: ss.2838
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: Children with chronic kidney disease (CKD) suffer from decreased exercise capacity due to the uremic environment, protein-energywasting, oxidative stress, and inflammation. Low levels of irisin, a recently discovered exercise-induced myokine, have been linked to adverse metabolic outcomes. The aim of this study was to evaluate the serum irisin levels in children with CKD and to analyze its potential associations with body composition, estimated glomerular filtration rate (eGFR), markers of oxidative stress, and inflammation. Design and methods: This cross-sectional, single-center study enrolled 39 children with CKD (22 male, aged 7.7 to 20.7 years, 26 children CKD stage 3 and 4 and 13 CKD 5D) and age and gender compatible 29 healthy children. Standard deviation scores (SDS) of height and body mass index (BMI) for height age were calculated according to national percentiles. Body composition parameters were measured with the multiplefrequency bioimpedance device. Serum concentrations of irisin, CRP, TNF-alpha, total antioxidant capacity (TAS), and total oxidant capacity (TOS) were analyzed by ELISA assays. Results: The number of underweight, overweight, and obese children in the CKD group was 4 (10.3%), 5 (12.8%), and 7 (17.9%), respectively. Although there were no differences in BMI-SDS or body composition parameters between the patient and control groups, median serum irisin level was lower in the CKD group than in the control group (3.97 vs 4.54 ng/ml, p= 0.03). However, there was no difference in irisin levels between patients with CKD 3-4 and CKD 5D. Serum irisin levels showed no association with BMI-SDS, body composition parameters, eGFR, CRP, TNF-alpha, TAS, TOS, or serum lipid levels. Conclusions: This study demonstrates decreased serum irisin concentrations in pediatric CKD patients. However, there is no association of irisin with any body composition parameters, inflammatory or oxidative stress markers. Further studies are needed to investigate the factors affecting serum irisin levels in children with CKD.