Evaluation of the pathophysiological role of Fetuin A levels in adolescents with polycystic ovary syndrome

BAYRAMOĞLU E., Cetinkaya S., Ozalkak S., Kurnaz E., Demirci G., ÖZTÜRK H. S., ...More

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.34, no.7, pp.911-916, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1515/jpem-2020-0524
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.911-916
  • Keywords: fetuin-A, hyperandrogenism, hyperinsulinism, polycystic ovary syndrome, OXIDATIVE STRESS, INSULIN-RECEPTOR, OBESE WOMEN, A LEVELS, RESISTANCE, INHIBITOR, DIAGNOSIS, WEIGHT, CELLS, HEART
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Objectives: Polycystic ovary syndrome ( PCOS) is an endocrinopathy, in which hyperandrogenism and hyperinsulinism have both occurred. Fetuin-A, a natural inhibitor of tyrosine kinase, leads to insulin resistance. The aim was to evaluate the relationship between fetuin-A and hyperandrogenism and hyperinsulinism and the role of fetuin-A in the pathophysiology of PCOS.