A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion


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Dogu O., Johnson J., Hernandez D., Hanson M., Hardy J., Apaydin H. , ...More

MOVEMENT DISORDERS, vol.19, no.7, pp.812-816, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1002/mds.20028
  • Title of Journal : MOVEMENT DISORDERS
  • Page Numbers: pp.812-816
  • Keywords: parkin, genetics, dystonia, depression, RECESSIVE JUVENILE PARKINSONISM, GENE, MUTATIONS

Abstract

The importance of parkin in early-onset Parkin-

son’s disease in Japan, Europe, and the United States is well

established. The contribution of this gene to the risk of

Parkinson’s disease in other populations is less well known.

To explore the importance of parkin in those of Turkish

ancestry, we studied familial cases from that country, and

identified a consanguineous family with early-onset Parkin-

son’s disease due to a homozygous mutation in

parkin

The importance of parkin in early-onset Parkin-
son’s disease in Japan, Europe, and the United States is well
established. The contribution of this gene to the risk of
Parkinson’s disease in other populations is less well known.
To explore the importance of parkin in those of Turkish
ancestry, we studied familial cases from that country, and
identified a consanguineous family with early-onset Parkin-
son’s disease due to a homozygous mutation in
parkin
.
The importance of parkin in early-onset Parkin-
son’s disease in Japan, Europe, and the United States is well
established. The contribution of this gene to the risk of
Parkinson’s disease in other populations is less well known.
To explore the importance of parkin in those of Turkish
ancestry, we studied familial cases from that country, and
identified a consanguineous family with early-onset Parkin-
son’s disease due to a homozygous mutation in
parkin
.
The importance of parkin in early-onset Parkin-
son’s disease in Japan, Europe, and the United States is well
established. The contribution of this gene to the risk of
Parkinson’s disease in other populations is less well known.
To explore the importance of parkin in those of Turkish
ancestry, we studied familial cases from that country, and
identified a consanguineous family with early-onset Parkin-
son’s disease due to a homozygous mutation in
parkin
.
The importance of parkin in early-onset Parkinson's disease in Japan, Europe, and the United States is well established. The contribution of this gene to the risk of Parkinson's disease in other populations is less well known. To explore the importance of parkin in those of Turkish ancestry, we studied familial cases from that country, and identified a consanguineous family with early-onset Parkinson's disease due to a homozygous mutation in parkin. (C) 2004 Movement Disorder Society.