H<sub>2</sub>O<sub>2</sub>-Producing Electrochemical Bandages Are Active Using Off-the-Shelf Hydrogels

Dagsuyu E., Kies P., Patel R., Beyenal H.

WOUND REPAIR AND REGENERATION, cilt.33, sa.5, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1111/wrr.70092
  • Dergi Adı: WOUND REPAIR AND REGENERATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

An electrochemical bandage (e-bandage) that generates hydrogen peroxide (H2O2) through a combination of working, counter and reference electrodes used with an electrolyte-providing hydrogel is being developed for wound infection management. e-Bandage biocidal activity was previously demonstrated using Xanthan gum hydrogel. For clinical use, clinically used hydrogels would be ideal, but their use with the described e-bandage has not been shown. The goal of this work was to evaluate the biocidal activity of off-the-shelf, clinically used hydrogels when used with a 1.77 cm(2) H2O2-producing e-bandage. e-Bandage electrochemical parameters and activity against methicillin-resistant Staphylococcus aureus IDRL-6169 and Acinetobacter baumannii ATCC-17978 biofilms were assessed with six off-the-shelf hydrogels. Variations in hydrogel composition affected electrochemical parameters, which was associated with differences in biocidal activity. Results of this study inform the selection of off-the-shelf hydrogels for use with H2O2-producing e-bandages.