A Role for Heterozygosity of NF-kappa B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia
ARCHIVES OF IRANIAN MEDICINE, cilt.19, ss.275-281, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19
- Basım Tarihi: 2016
- Dergi Adı: ARCHIVES OF IRANIAN MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.275-281
- Anahtar Kelimeler: NE-kappa B1 and NF-kappa BIA polymorphisms, male infertility, oligospermic, idiopathic, apoptosis, NF-KAPPA-B, NFKB1 PROMOTER POLYMORPHISM, INCREASED APOPTOSIS, IN-SITU, SPERM, RISK, TRANSCRIPTION, SPERMATOZOA, EXPRESSION, PATHWAY
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Background: Nuclear factor-kappa B (NF-kB) activation and its inhibition by NF-kB inhibitor (IkB) have been functionally linked to germ cell apoptosis, which may affect human infertility. We hypothesized a possible relationship between the NF-kappa B1-94insidel ATTG (rs28362491) and NF-kappa BIA 3'UTR A -> G (rs696) polymorphism, which are common polymorphisms and the susceptibility to oligospermia in the context of the sperm apoptosis.