A Role for Heterozygosity of NF-kappa B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia

Tek B., Elcin P., Tunçdemir M., Onaran I., Özkara H., Sultuybek G. K.

ARCHIVES OF IRANIAN MEDICINE, cilt.19, ss.275-281, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2016
  • Dergi Adı: ARCHIVES OF IRANIAN MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.275-281
  • Anahtar Kelimeler: NE-kappa B1 and NF-kappa BIA polymorphisms, male infertility, oligospermic, idiopathic, apoptosis, NF-KAPPA-B, NFKB1 PROMOTER POLYMORPHISM, INCREASED APOPTOSIS, IN-SITU, SPERM, RISK, TRANSCRIPTION, SPERMATOZOA, EXPRESSION, PATHWAY
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background: Nuclear factor-kappa B (NF-kB) activation and its inhibition by NF-kB inhibitor (IkB) have been functionally linked to germ cell apoptosis, which may affect human infertility. We hypothesized a possible relationship between the NF-kappa B1-94insidel ATTG (rs28362491) and NF-kappa BIA 3'UTR A -> G (rs696) polymorphism, which are common polymorphisms and the susceptibility to oligospermia in the context of the sperm apoptosis.