Akademik Veri Yönetim Sistemi
Archives of Clinical and Experimental Medicine, cilt.5, sa.1, ss.1-5, 2020 (Hakemli Dergi)
Aim: It has been reported that repeated sevoflurane exposure induces cognitive impairment. On the other hand,there is evidence that rivastigmine can attenuate or antagonize the cognitive dysfunctions caused by anestheticagents. The aims of this study were to determine the effect of repeated sevoflurane exposure on spatial learningand memory (SLM) in weanling rats and to assess whether rivastigmine provides protection against theneurotoxic effects of sevoflurane at this early developmental stage.Methods: Thirty-two weanling rats were randomly divided into four equal groups: sevoflurane (S: 2%sevoflurane for 2 hours), sevoflurane + rivastigmine (SR: 2% sevoflurane and 2 mg/kg rivastigmine),rivastigmine (R: 2 mg/kg), and control (C: 100% oxygen for 2 hours). Rats were treated four times over 10 days.Four days after the last treatment, the rats were subjected to a Morris water maze test protocol to examine SLM.Results: The escape latencies of all groups gradually decreased day by day during the training trials performedto evaluate spatial learning (ρ<0.05). Group R showed more improvement than other groups as the rats in thisgroup learned significantly more slowly on the first and second days of the training trials but reached the samelevels as Group S and Group SR on the third and last days (ρ<0.05). In the probe trial to evaluate spatialmemory, no significant difference was found among the groups for time spent in the ‘platform’ quadrant(ρ>0.05).Conclusion: Sevoflurane negatively affects learning in weanling rat pups but has no detrimental effect on spatialmemory. On the other hand, it can be claimed that sevoflurane offsets the memory-sparing effects ofrivastigmine