Expression of genes related to iron homeostasis in breast cancer

Mutlu T., Ozoran E., Trabulus D. C., Talu C. K., Erhan D., Mete M., ...Daha Fazla

MOLECULAR BIOLOGY REPORTS, cilt.50, sa.6, ss.5157-5163, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s11033-023-08433-1
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.5157-5163
  • Anahtar Kelimeler: Iron homeostasis genes, Breast cancer, Gene expression, TFRC, IRP1, miR-122, HEPCIDIN, METABOLISM, GROWTH
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular expression in genes associated with iron metabolism. The variations are related to findings that have prognostic significance. This study evaluated the relationship of the expression levels of transferrin receptor 1 (TFRC), iron regulatory protein 1 (IRP1), hepcidin (HAMP), ferroportin 1 (FPN1), hemojuvelin (HFE2), matriptase 2 (TMPRSS6), and miR-122 genes in the normal and malignant tissues of breast cancer patients.