The effects of vitamin E on lipid peroxidation, nitric oxide production, and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury

Gumustas K., Guzeyli F. M., Atukeren P., Sanus G. Z., Kemerdere R., Tanriverdi T., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.17, sa.2, ss.78-82, 2007 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2007
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.78-82
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

OBJECTIVES: Recent studies have revealed that nitric oxide (NO) in concert with lipid peroxidation (LP) may play an important role in pathophysiological mechanism(s) of cerebral ischemia. In addition, hyperglycemia exaggerates the pathological changes during cerebral ischemia. The purpose of this study was to investigate the effects of vitamin E (VE) on LP, NO production, and superoxide dismutase (SOD) expression in hyperglycemic rats after cerebral ischemia-reperfusion injury.