A review on the dosimetrical and radiobiological prediction of radiation-induced hypothyroidism in radiation therapy of head-and-neck cancer, breast cancer, and Hodgkin's lymphoma survivors

Mohammad Namdar A., Mohammadzadeh M., Okutan M., Mesbahi A.

POLISH JOURNAL OF MEDICAL PHYSICS AND ENGINEERING, cilt.24, sa.4, ss.137-148, 2018 (ESCI, Scopus) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2478/pjmpe-2018-0020
  • Dergi Adı: POLISH JOURNAL OF MEDICAL PHYSICS AND ENGINEERING
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.137-148
  • Anahtar Kelimeler: radiation therapy, hypothyroidism, head-and-neck cancer, breast cancer, Hodgkin's lymphoma, NTCP modelling, QUANTEC, COMPLICATION PROBABILITY-MODELS, NORMAL TISSUE, THYROID-DISORDERS, RETROSPECTIVE ANALYSIS, PARALLEL ARCHITECTURE, DOSE-RESPONSE, RADIOTHERAPY, RISK, IRRADIATION, DYSFUNCTION
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

A review on the radiobiological modeling of radiation-induced hypothyroidism after radiation therapy of head-and-neck cancers, breast cancer, and Hodgkin's lymphoma is presented. The current review is based on data relating to dose-volume constrains and normal tissue complication probability (NTCP) as a function of either radiobiological or (pre)treatment-clinical parameters. Also, these data were explored in order to provide more helpful criteria for radiobiological optimization of treatment plans involving thyroid gland as a critical normal organ.