Novel alterations in superoxide dismutase and catalase activities in the female rabbit bladder subjected to hormonal manipulations

Onal B., LEVIN R. M., KOGAN B. A., GUVEN A., LEGGETT R. E., MANNIKAROTTU A. S.

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.39, sa.4, ss.1049-1054, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s11255-007-9176-z
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1049-1054
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Objectives Previous studies have demonstrated that ovariectomy induces reduced blood flow and hypoxia, resulting in free radical damage of the mucosal and smooth muscle compartments of the rabbit urinary bladder, whereas estradiol administration results in angiogenesis and recovery from hypoxia. The current study was designed to investigate the effects of ovariectomy and estradiol replacement on the superoxide dismutase (SOD) and catalase (CAT) activities of the bladder.