Akademik Veri Yönetim Sistemi
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, cilt.37, sa.10, ss.1633-43, 2016 (SCI-Expanded, Scopus)
Vitamin D is a secosteroid hormone that shares a synthetic pathway with cholesterol. ApoE, which is involved in the transport of cholesterol, is the most significant genetic risk factor for sporadic Alzheimer's disease (AD). Surprisingly, recent studies have indicated the presence of an evolutionary juncture between these two molecules. To demonstrate this possible relationship, we investigated serum levels of 25-hydroxyvitamin-D-3 (25OHD) in patients with early onset-AD (EOAD; n:22), late onset-AD (LOAD; n:72), mild cognitive impairment (MCI; n:32) and in healthy subjects (n:70). We then analyzed the correlation between 25OHD and cytokines, BDNF and Hsp90 with respect to ApoE alleles, as these molecules were investigated in our previous studies. The LOAD patients had low levels of 25OHD, but these low levels originated only from ApoEE > 4 non-carrier patients. Negative correlations were observed between serum 25OHD and TNF alpha, IL-1 beta or IL-6 levels in healthy subjects or MCI patients, but these same correlations were positive in LOAD patients. ApoE alleles indicated that these positive correlations exist only in E > 4 carrier LOAD patients. Consequently, our results indicate that vitamin D deficiency presents a greater risk for ApoEE > 4 non-carrier AD patients than for E > 4 carriers. Therefore, it might be beneficial to monitor the vitamin D status of ApoEE > 4 allele non-carrier AD patients.