The role of mediastinal adipose tissue 11 beta-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease

Atalar, Fatmahan; Gormez, Selcuk; Caynak, Baris; Akan, Gokce; Tanriverdi, GAMZE; Bilgic-Gazioglu, Sema; Gunay, Demet; Duran, Cihan; Akpinar, Belhhan; Ozbek, Ugur; Buyukdevrim, Ahmet; Yazici, Zeliha

doi:10.1186/1475-2840-11-115

The role of mediastinal adipose tissue 11 beta-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease

Atalar F., Gormez S., Caynak B., Akan G., Tanriverdi G., Bilgic-Gazioglu S., ...More

CARDIOVASCULAR DIABETOLOGY, vol.11, 2012 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 11
Publication Date: 2012
Doi Number: 10.1186/1475-2840-11-115
Journal Name: CARDIOVASCULAR DIABETOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Mediastinal adipose tissue, Glucocorticoid, Inflammation, Coronary artery disease, Stearidonic acid, Cortisol, ECHOCARDIOGRAPHIC EPICARDIAL FAT, DEHYDROGENASE TYPE-1, METABOLIC SYNDROME, CARDIOMETABOLIC RISK, VISCERAL OBESITY, PERICARDIAL FAT, INSULIN-RESISTANCE, MESSENGER-RNA, INFLAMMATION, CORTISOL
Open Archive Collection: AVESIS Open Access Collection
Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background: Visceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue (MAT) and epicardial adipose tissue (EAT), and MAT is a potential biomarker of risk for obese patients.