Roles of i>OLR1/i> and i>IL17A/i> variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery
TURKISH JOURNAL OF BIOCHEMISTRY, cilt.47, sa.5, ss.571-579, 2022 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1515/tjb-2021-0214
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.571-579
- Anahtar Kelimeler: coronary artery disease, genetic variant, IL17A, OLR1, oxidative stress, rs11053646, rs3819025, rs8193037, LOW-DENSITY-LIPOPROTEIN, 3'-UTR-C188T POLYMORPHISMS, LECTIN-LIKE, RISK, INTERLEUKIN-17A, ASSOCIATION, DISEASE, RECEPTOR-1, EXPRESSION, PROTEIN
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Objectives: Coronary artery disease (CAD) is a pathological
condition resulting from atherosclerosis in the coronary
arteries. IL17A has been shown to recruit and activate
macrophages in atherosclerotic lesions, thereby participating
in plaque destabilization. Currently, whether OLR1
and IL17A variants are involved in the pathogenesis of CAD
is unclear. This case-control study aimed to investigate
their roles in CAD etiology and prognosis.
Methods: In this study, 100 severe CAD patients who had
undergone the coronary artery bypass graft surgery and
100 healthy controls were genotyped for OLR1 rs11053646,
IL17A rs3819025, and rs8193037 variants via RT-PCR.
Results: The patients with OLR1 rs11053646 CG + GG
genotype demonstrated a higher frequency of multi-vessel
stenosis (18%) than single- (11.10%) or double-vessel
(13.30%) stenosis (p=0.77). Additionally, although not
statistically significant, this group of patients had 6.280
times more CAD risk than CC genotype carriers (p=0.089).
Furthermore, logistic regression analysis revealed significant
associations between the three variants and the risk
factors for CAD development, namely waist circumference
(p=0.002), body mass index (p=0.013), fasting glucose
level (p=0.006), and triglyceride levels (p=0.035).
Conclusions: OLR1 rs11053646, IL17A rs3819025, and
rs8193037 variants do not increase the risk for CAD development.
However, this conclusion should be confirmed
with a larger cohort.