Roles of i>OLR1/i> and i>IL17A/i> variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery

Recep E., Bayoglu B., Arslan C., Goksedef D., Ipek G.

TURKISH JOURNAL OF BIOCHEMISTRY, cilt.47, sa.5, ss.571-579, 2022 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1515/tjb-2021-0214
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.571-579
  • Anahtar Kelimeler: coronary artery disease, genetic variant, IL17A, OLR1, oxidative stress, rs11053646, rs3819025, rs8193037, LOW-DENSITY-LIPOPROTEIN, 3'-UTR-C188T POLYMORPHISMS, LECTIN-LIKE, RISK, INTERLEUKIN-17A, ASSOCIATION, DISEASE, RECEPTOR-1, EXPRESSION, PROTEIN
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objectives: Coronary artery disease (CAD) is a pathological

condition resulting from atherosclerosis in the coronary

arteries. IL17A has been shown to recruit and activate

macrophages in atherosclerotic lesions, thereby participating

in plaque destabilization. Currently, whether OLR1

and IL17A variants are involved in the pathogenesis of CAD

is unclear. This case-control study aimed to investigate

their roles in CAD etiology and prognosis.

Methods: In this study, 100 severe CAD patients who had

undergone the coronary artery bypass graft surgery and

100 healthy controls were genotyped for OLR1 rs11053646,

IL17A rs3819025, and rs8193037 variants via RT-PCR.

Results: The patients with OLR1 rs11053646 CG + GG

genotype demonstrated a higher frequency of multi-vessel

stenosis (18%) than single- (11.10%) or double-vessel

(13.30%) stenosis (p=0.77). Additionally, although not

statistically significant, this group of patients had 6.280

times more CAD risk than CC genotype carriers (p=0.089).

Furthermore, logistic regression analysis revealed significant

associations between the three variants and the risk

factors for CAD development, namely waist circumference

(p=0.002), body mass index (p=0.013), fasting glucose

level (p=0.006), and triglyceride levels (p=0.035).

Conclusions: OLR1 rs11053646, IL17A rs3819025, and

rs8193037 variants do not increase the risk for CAD development.

However, this conclusion should be confirmed

with a larger cohort.