A Genetic Assessment of Dopamine Agonist-Induced Impulse Control Disorder in Patients With Prolactinoma

Sahin S., Sudutan T., Kavla Y., Durcan E., Özogul Y. Y., Poyraz B. Ç., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.108, no.6, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1210/clinem/dgac718
  • Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, Food Science & Technology Abstracts, Gender Studies Database, Veterinary Science Database, Nature Index
  • Keywords: dopamine agonist, impulse control disorder, polymorphism, prolactinoma, GRIN2B GENE, BEHAVIORAL ADDICTIONS, PARKINSONS-DISEASE, RISK-TAKING, ASSOCIATION, POLYMORPHISMS, VARIANT, CHOICE, DRD3
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Context Dopamine agonist (DA)-induced impulse control disorder (ICD) represents a group of behavioral disorders that are increasingly recognized in patients with prolactinoma. Objective We aimed to examine the genetic component of the underlying mechanism of DA-induced ICD. Methods Patients with prolactinoma receiving dopamine agonist (cabergoline) treatment were included in the study. These patients were divided into 2 groups: patients who developed ICD due to DA and patients who did not. Patients were evaluated for polymorphisms of the DRD1, DRD3, COMT, DDC, GRIN2B, TPH2, OPRK1, OPRM1, SLC6A4, SLC6A3, HTR2A genes. Results Of the 72 patients with prolactinoma using cabergoline, 20 were diagnosed with ICD. When patients with and without ICD were compared according to genotype frequencies, OPRK1/rs702764, DRD3/rs6280, HTR2A/rs6313, SLC6A4/rs7224199, GRIN2B/rs7301328, TPH2/rs7305115, COMT/rs4680, DRD1/rs4532 polymorphisms significantly increased in patients with DA-induced ICD. Conclusion Our results show that multiple neurotransmission systems affect DA-induced ICD in patients with prolactinoma.