Relationship Between Carotid Intima-Media Thickness and Osteoporosis in Type 2 Diabetic Patients: Cross-Sectional Study in the Third-Level Center.

Güneş M., Kara Z., Yavuzer S., Yavuzer H., Bolayirli İ. M., Oşar Siva Z.

Metabolic syndrome and related disorders, cilt.20, ss.592-598, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1089/met.2022.0008
  • Dergi Adı: Metabolic syndrome and related disorders
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.592-598
  • Anahtar Kelimeler: subclinical atherosclerosis, osteoporosis, bone turnover, BONE-MINERAL DENSITY, SUBCLINICAL ATHEROSCLEROSIS, FRACTURE RISK, MELLITUS, MARKERS, WOMEN, MEN, OSTEOPROTEGERIN, CALCIFICATION, TURNOVER
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Aim: Although atherosclerosis and osteoporosis (OP) are seen in elderly patients, it is still a matter of research whether there is an age-independent relationship between them. In our study, we planned to investigate the relationship between carotid intima-media thickness (CIMT), OP, and bone turnover parameters in patients with type 2 diabetes mellitus (DM2) of both sexes.Materials and Methods: A total of 69 patients and 40 healthy volunteers with chronic diseases such as DM2, hypertension, hyperlipidemia, and OP. Group 1 had 27 patients with DM2 and OP, group 2 had 42 patients with DM2 and no OP, and group 3 had 40 healthy volunteers without DM2 and OP.Results: In the control group, CIMT was measured lower than the patients with DM2 (0.8 + 0.1 and 1.1 + 0.3, P < 0.001, respectively). Femur T score and lumbar T score values of patients with DM2 were lower than the control group (-0.48 + 1.1 and 0.7 + 0.6, P < 0.001, and -1.3 + 1.5 and 0.6 + 0.5, P < 0.001, respectively). Bone turnover markers in DM2 compared to the control group (C-terminal telopeptide of type 1 collagen: 240.9 +/- 211.1 and 606.5 +/- 200.8, P < 0.001; bone-specific alkaline phosphatase: 47.9 +/- 15.5 and 431.5 +/- 140, P < 0.001; and osteocalcin: 13.2 +/- 5.0 and 19.7 +/- 9.2, P < 0.001, respectively) were lower. Patients with femoral region (TSF) T score and lumbar region (TSL) T score below -2.5 were found to have higher CIMT values than those without (1.2 +/- 0.23 mm and 0.9 +/- 0.23 mm, P = 0.006, and 1.1 +/- 0.28 mm and 0.95 +/- 0.21 mm, P = 0.003, respectively). In linear regression analysis, age (beta = 0.01, P < 0.001), OP (beta = 0.166, P = 0.001), and DDM2 (beta = 0.222, P = 0.04) were found to be effective on CIMT, while DM2 (beta) = -0.754, P < 0.001), CIMT (beta = -0.258, P = 0.021), body mass index (beta = 0.355, P = 0.028), and age (beta = -0.229, P = 0.029) were found to be independent factors on TSF.Conclusion: Bone turnover and bone mineral density are decreased in DM2 patients. In addition, subclinical atherosclerosis is more common in DM2 patients. Findings suggest that there is a relationship between subclinical atherosclerosis and OP due to metabolic factors other than age.